Cellular Strategies of Protein Quality Control
نویسندگان
چکیده
منابع مشابه
Cellular strategies of protein quality control.
Eukaryotic cells must contend with a continuous stream of misfolded proteins that compromise the cellular protein homeostasis balance and jeopardize cell viability. An elaborate network of molecular chaperones and protein degradation factors continually monitor and maintain the integrity of the proteome. Cellular protein quality control relies on three distinct yet interconnected strategies whe...
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The folding of secretory and membrane proteins takes place in the endoplasmic reticulum (ER). The quality of the proteins folded in the ER is carefully monitored by an ER quality control mechanism that allows only correctly folded proteins to be transported to their final destination, and misfolded or unassembled proteins to be retained in the ER and subsequently degraded in a process termed ‘E...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2011
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a004374